In platelet single donor apheresis, platelet factor 4 levels correlated with donor's age and decreased during storage

AC Duchez, M Heestermans, CA Arthaud… - Scientific Reports, 2024 - nature.com
The human population is ageing worldwide. The World Health Organization estimated that
the world's population of people aged 60 years and older will increase to at least 30 …

“Bloody” good factors for keeping the brain young

TJ Stevenson, L Vinnell, J Rustenhoven - Immunity, 2023 - cell.com
The increasing burden in dementia-related disorders has necessitated improved
understanding of cognitive decline. In a recent issue of Nature, Schroer et al. demonstrate …

Peripheral to brain and hippocampus crosstalk induced by exercise mediates cognitive and structural hippocampal adaptations

GR Blume, LFF Royes - Life Sciences, 2024 - Elsevier
Endurance exercise leads to robust increases in memory and learning. Several exercise
adaptations occur to mediate these improvements, including in both the hippocampus and in …

Harnessing Agent-Based Modeling in CellAgentChat to Unravel Cell-Cell Interactions from Single-Cell Data

V Raghavan, Y Li, J Ding - bioRxiv, 2023 - biorxiv.org
Deciphering cell-cell interactions is crucial yet challenging, given the inherent intricacy and
heterogeneity of cellular dynamics within biological systems. Existing methodologies …

Regenerative rehabilitation measures to restore tissue function after arsenic exposure

AA Jasper, KH Shah, H Karim, S Gujral… - Current Opinion in …, 2024 - Elsevier
Environmental exposure of arsenic impairs cardiometabolic profile, skeletal muscle health,
and neurological function. Such declining tissue health is observed as early as in one's …

Intense exercise at high altitude causes platelet loss across the brain in humans

TD Gibbons, HG Caldwell, H Islam… - The Journal of …, 2024 - Wiley Online Library
Platelets are known primarily for their role in blood clotting; however, it is becoming clear
that they play diverse roles beyond that of haemostasis. Exercise has been shown to …

Platelet Factor 4 and Longevity of Patients with Essential Thromobocythemia: An Example of Antagonistic Pathogenic Pleiotropy

W Bains - Rejuvenation Research, 2024 - liebertpub.com
This paper presents the concept of Antagonistic Pathogenic Pleiotropy (APaP), in which an
abnormality that causes a specific pathology can simultaneously reduce other morbidities …

Selenoprotein P in a Rodent Model of Exercise; Theorizing Its Interaction with Brain Reward Dysregulation, Addictive Behavior, and Aging

P Mohr, C Hanna, A Powell, S Penman, K Blum… - Journal of Personalized …, 2024 - mdpi.com
Exercise promotes health and wellness, including its operation as a protective factor against
a variety of psychological, neurological, and chronic diseases. Selenium and its biomarker …

A platelet-derived factor protects the ageing brain

Y Bordon - Nature Reviews Immunology, 2023 - nature.com
A platelet-derived factor protects the ageing brain | Nature Reviews Immunology Skip to
main content Thank you for visiting nature.com. You are using a browser version with …

Rejuvenation of young blood on aging organs: Effects, circulating factors, and mechanisms

MN Liu, Q Lan, H Wu, CW Qiu - Heliyon, 2024 - cell.com
Aging causes degenerative changes in organs, leading to a decline in physical function.
Over the past two decades, researchers have made significant progress in understanding …