T cell receptor diversity in alloreactive responses against HLA‐B27 (B* 2705) is limited by multiple‐level restrictions in both α and β chains

DF Barber, D López… - European journal of …, 1995 - Wiley Online Library
The T cell receptors (TCR) in HLA‐B27 (B* 2705) alloreactivity were analyzed in cytotoxic T
lymphocytes (CTL) from two individuals. Non‐random usage was found in Vβ, N+ Dβ, Vα …

Analysis of the requirements for class II-restricted T cell recognition of a single determinant reveals considerable diversity in the T cell response and degeneracy of …

AM Fahrer, HM Geysen, DO White… - … (Baltimore, Md.: 1950 …, 1995 - journals.aai.org
The amino acid sequences recognized by five IE (d)-restricted and one E alpha A beta d-
restricted murine T cell clones were determined. The clones had been raised to a synthetic …

Subset-specific transduction of CD4+ and CD8+ T cells in vivo

CP Kemna - 2023 - refubium.fu-berlin.de
T cell-based immunotherapy is a promising approach in treating haematological and solid
malignancies. The specificity of a T cell is determined by its T cell receptor (TCR). The TCR …

[PDF][PDF] Foreign peptides expressed in engineered chimeric self molecules

S Casares, A Bot, TD Brumeanu… - … and Genetic Engineering …, 1998 - Taylor & Francis
Antigens are macromolecules that interact with specific lymphocyte receptors: B-cell
immunoglobulin receptor (lgR) and T... cell antigen receptor (TCR). The antigen is …

Heterogeneity of T cells specific for a particular peptide/HLA-DQ complex

A Spurkland, T Gedde-Dahl III, T Hansen, F Vartdal… - Human immunology, 1994 - Elsevier
Whether T cells specific for a particular peptide/HLA-DQ complex are restricted with respect
to TCR usage has not been fully established. TCR usage of T cells specific for a peptide …

Presentation of a viral peptide assembled on the carbohydrate moieties of immunoglobulin does not require processing

TD Brumeanu, S Casares, P Dehazya… - European journal of …, 1997 - Wiley Online Library
We have previously demonstrated that an immunodominant CD4 T cell epitope, HA110‐120
of the hemagglutinin (HA) of the A/PR/8/34 influenza virus, enzymatically assembled on the …

Both H-2-and non-H-2-linked genes influence influenza nucleoprotein epitope recognition by CD4+ T cells.

SJ Brett, JP Tite - Immunology, 1996 - ncbi.nlm.nih.gov
The specificity of the influenza nucleoprotein-induced T-cell proliferative response by mouse
strains differing in either H-2-or non-H-2-linked background genes was compared by using a …

[图书][B] Spontaneous model of experimental autoimmune uveoretinitis: irbp-hel transgenic mice

K Makinen - 2006 - search.proquest.com
To generate a spontaneous EAU model, transgenic mice expressing membrane-bound hen
egg lysozyme (HEL) under control of the IRBP promoter were generated. The mice …

[图书][B] Evaluating the Immunogenic Potential of Synthetic Influenza TB & BT Peptides

L Samayoa - 2012 - search.proquest.com
Vaccination is one of the major strategies available for combating viral infections in humans.
However, currently available vaccines are not without pitfalls; they are laborious to produce …

Selective Enrichment of Major Histocompatibility Complex Class R-specific Autoreactive T Cells in the Thymic Thy0 Subset By Ilona Kariv, Richard R. Hardy, and …

TT Subset - ncbi.nlm.nih.gov
We show here a unique enrichment of autoreactive T cells in the CD4+ mouse thymic
subset, Thy0. A single-and 10-cell AMLR (autologous mixed leukocyte reaction) assay …