[HTML][HTML] The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: implications for neural control of cardiac excitability

N Herring, J Cranley, MN Lokale, D Li, J Shanks… - Journal of molecular and …, 2012 - Elsevier
The autonomic phenotype of congestive cardiac failure is characterised by high sympathetic
drive and impaired vagal tone, which are independent predictors of mortality. We …

The role of neuropeptide Y in cardiovascular regulation

P Walker, E Grouzmann, M Burnier… - Trends in pharmacological …, 1991 - cell.com
Neumpeptidc Y (NPYJ is a 36 amino acid prptide present in the brain, the adrenal medulla
and peripheral sympathetic nerves. The localization and mode of release of NPY led to the …

Regional sympathetic effects of low-dose clonidine in heart failure

A Aggarwal, MD Esler, MJ Morris, G Lambert… - …, 2003 - Am Heart Assoc
This study examined the effects of low doses of intravenous clonidine on regional and global
sympathetic nervous system activity in heart failure. In heart failure, adrenoceptor-blocking …

[HTML][HTML] Cardiac sympathetic activation circumvents high-dose beta blocker therapy in part through release of neuropeptide Y

JD Hoang, S Salavatian, N Yamaguchi, MA Swid… - JCI insight, 2020 - ncbi.nlm.nih.gov
The sympathetic nervous system plays an important role in the occurrence of ventricular
tachycardia (VT). Many patients, however, experience VT despite maximal doses of beta …

Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway

N Herring, MN Lokale, EJ Danson, DA Heaton… - Journal of molecular and …, 2008 - Elsevier
The co-transmitter neuropeptide Y (NPY), released during prolonged cardiac sympathetic
nerve stimulation, can attenuate vagal-induced bradycardia. We tested the hypothesis that …

Agonist‐induced desensitisation of β3‐adrenoceptors: Where, when, and how?

K Okeke, S Angers, M Bouvier… - British journal of …, 2019 - Wiley Online Library
β3‐Adrenoceptor agonists have proven useful in the treatment of overactive bladder
syndrome, but it is not known whether their efficacy during chronic administration may be …

Low urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure

L Girotti, M Lago, O Ianovsky, MV Elizari, A Dini… - Endocrine, 2003 - Springer
Objective: To assess urinary 6-sulfatoxymelatonin excretion in patients admitted to the
hospital because of congestive heart failure (CHF). Methods: Urinary 6-sulfatoxymelatonin …

Adrenomedullin, endothelin, neuropeptide Y, atrial, brain, and C-natriuretic prohormone peptides compared as early heart failure indicators

S Daggubati, JR Parks, RM Overton… - Cardiovascular …, 1997 - academic.oup.com
Objectives: The present investigation was designed to determine the best endogenous
plasma marker of early congestive heart failure (CHF). Methods: Forty volunteers with mild …

Evidence for functional presynaptic alpha-2 adrenoceptors and their down-regulation in human heart failure

A Aggarwal, MD Esler, F Socratous, DM Kaye - Journal of the American …, 2001 - jacc.org
OBJECTIVES The aim of this study was to investigate the role of peripheral presynaptic
alpha-2 adrenergic receptors in modulating norepinephrine (NE) release in congestive heart …

Renal effects of neuropeptide Y

A Bischoff, MC Michel - Pflügers Archiv, 1998 - Springer
Neuropeptide Y (NPY) is a co-transmitter of the sympathetic nervous system including the
renal nerves. The kidney expresses NPY receptors, which can also be activated by peptide …