Abstract α2-adrenoceptor (α2-AR) isoforms, abundant in sympathetic synapses and
noradrenergic neurons of the central nervous system, are integral in the presynaptic feed …

BACKGROUND Sympathetic excitation characterizes heart failure, but the underlying
mechanisms remain unknown. Abnormal baroreflex restraint of sympathetic neural outflow …

Neuropeptide Y (NPY) binding sites in rat cardiac ventricular membranes have been
characterized in detail. 125 I-NPY bound to the membranes with high affinity. Binding was …

Congestive heart failure (CHF) and pulmonary edema are major health problems in the
United States as well as across the rest of the developing world. The prevalence of CHF and …

[D-Trp32] NPY shifted the inhibitory dose-response curve of NPY on isoproterenol-
stimulated hypothalamic membrane adenylate cyclase activity parallel tothe right with …

The increased neuroendocrine activity in patients with congestive heart failure appears to be
a generalized attempt to maintain blood pressure at the expense of reduced cardiac …

Dipeptidyl peptidase IV (DPPIV) is a widely expressed multifunctional serine peptidase that
exists as a membrane-anchored cell surface protein or in a soluble form in the plasma and …

Stress triggers responses important to maintain internal homeostasis, and yet when
prolonged can cause medical consequences that are most likely mediated by changes in …

Hypertension often occurs with fluid overload. The most common mechanism is considered
to be mediated by increased cardiac output. Hemodialysis (HD) patients frequently have …

OBJECTIVE--To measure plasma concentrations of noradrenaline and neuropeptide Y-like
immunoreactivity in relation to cardiac function in patients with congestive heart failure …