Acute myeloid leukemia: 2023 update on diagnosis, risk‐stratification, and management
Disease overview Acute myeloid leukemia (AML) is a frequently fatal bone marrow stem cell
cancer characterized by unbridled proliferation of malignant marrow stem cells with …
cancer characterized by unbridled proliferation of malignant marrow stem cells with …
Recent advances in targeted therapies in acute myeloid leukemia
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. While survival
for younger patients over the last several decades has improved nearly sixfold with the …
for younger patients over the last several decades has improved nearly sixfold with the …
International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data
The classification of myeloid neoplasms and acute leukemias was last updated in 2016
within a collaboration between the World Health Organization (WHO), the Society for …
within a collaboration between the World Health Organization (WHO), the Society for …
Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia
EJ Duncavage, A Bagg, RP Hasserjian… - Blood, The Journal …, 2022 - ashpublications.org
Myeloid neoplasms and acute leukemias derive from the clonal expansion of hematopoietic
cells driven by somatic gene mutations. Although assessment of morphology plays a crucial …
cells driven by somatic gene mutations. Although assessment of morphology plays a crucial …
Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN
The 2010 and 2017 editions of the European LeukemiaNet (ELN) recommendations for
diagnosis and management of acute myeloid leukemia (AML) in adults are widely …
diagnosis and management of acute myeloid leukemia (AML) in adults are widely …
C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3-Mutant Leukemia
M Sabatier, R Birsen, L Lauture, S Mouche, P Angelino… - Cancer Discovery, 2023 - AACR
Although transcription factor CCAAT-enhancer binding protein α (C/EBPα) is critical for
normal and leukemic differentiation, its role in cell and metabolic homeostasis is largely …
normal and leukemic differentiation, its role in cell and metabolic homeostasis is largely …
Comparison and validation of the 2022 European LeukemiaNet guidelines in acute myeloid leukemia
CA Lachowiez, N Long, J Saultz, A Gandhi… - Blood …, 2023 - ashpublications.org
Risk stratification in acute myeloid leukemia (AML) remains principle in survival
prognostication and treatment selection. The 2022 European LeukemiaNet (ELN) …
prognostication and treatment selection. The 2022 European LeukemiaNet (ELN) …
The International Consensus Classification of acute myeloid leukemia
OK Weinberg, A Porwit, A Orazi, RP Hasserjian… - Virchows Archiv, 2023 - Springer
Acute myeloid leukemias (AMLs) are overlapping hematological neoplasms associated with
rapid onset, progressive, and frequently chemo-resistant disease. At diagnosis, classification …
rapid onset, progressive, and frequently chemo-resistant disease. At diagnosis, classification …
Validation and refinement of the 2022 European LeukemiaNet genetic risk stratification of acute myeloid leukemia
C Rausch, M Rothenberg-Thurley, A Dufour… - Leukemia, 2023 - nature.com
Abstract The revised 2022 European LeukemiaNet (ELN) AML risk stratification system
requires validation in large, homogeneously treated cohorts. We studied 1118 newly …
requires validation in large, homogeneously treated cohorts. We studied 1118 newly …
AML classification in the year 2023: How to avoid a Babylonian confusion of languages
S Huber, C Baer, S Hutter, F Dicker, M Meggendorfer… - Leukemia, 2023 - nature.com
In parallel to the 5th edition of the World Health Organization Classification of
Haematolymphoid Tumours (WHO 2022), an alternative International Consensus …
Haematolymphoid Tumours (WHO 2022), an alternative International Consensus …