In this study, we investigated the effects of interleukin-1β (IL-1β), a typical proinflammatory
cytokine on the β-adrenoreceptor-stimulated induction of uncoupling protein 1 (UCP1) …

Uncoupling protein (UCP) 2 is a widely expressed mitochondrial protein whose precise
function is still unclear but has been linked to mitochondria-derived reactive oxygen species …

Both stimulatory and detrimental effects of NEFAs (non-esterified fatty acids) on pancreatic β-
cells have been recognized. Acute exposure of the pancreatic β-cell to high glucose …

Despite recent advances in therapy, heart failure remains a major cause of mortality and
morbidity and is a growing healthcare burden worldwide. Alterations in myocardial energy …

Reactive oxygen species (ROS) and insulin signaling in the adipose tissue are critical
determinants of aging and age-associated diseases. It is not clear, however, if they …

Sphingomyelin synthase 1 (SMS1) catalyzes the conversion of ceramide to sphingomyelin.
Here, we generated and analyzed SMS1-null mice. SMS1-null mice exhibited moderate …

The most commonly studied laboratory rodents possess a specialized form of fat called
brown adipose tissue (BAT) that generates heat to help maintain body temperature in cold …

Obesity is an increasingly serious socioeconomic and clinical problem. Between 1/4-1/3 of
population in the developed countries can be classified as obese. Four major etiological …

In a springtime Madrid, under the auspices of the Juan March Foundation, some 50
scientists who work on uncoupling proteins convened to debate the mode of action of these …

Recently, it has been demonstrated that uncoupling protein-1 (UCP1)-expressing white
adipocytes (brown-like adipocytes) are important for energy expenditure in white adipose …