Although leptin is a hormone mainly produced by the adipose tissue, it is also produced by
the gastric mucosa and the mammary epithelium and is present in maternal milk. The effects …

Mitochondria are fascinating organelles involved in various cellular-metabolic activities that
are integral for mammalian development. Although they perform diverse, yet interconnected …

The effect of thyroid hormones on metabolism has long supported their potential as drugs to
stimulate fat reduction, but the concomitant induction of a thyrotoxic state has greatly limited …

Mitochondrial dysfunction entailing decreased energy‐transducing capacity and perturbed
redox homeostasis is an early and sometimes initiating event in ageing and age‐related …

To examine the involvement of ghrelin in obesity, we investigated the effects of treatment
with peripherally administered ghrelin on food intake, adiposity, and expression of …

Proteins containing the zinc finger domain (s) are named zinc finger proteins (ZFPs), one of
the largest classes of transcription factors in eukaryotic genomes. A large number of ZFPs …

It has been reported that American ginseng attenuates hyperglycemia and may present itself
as a supplement to diabetes therapy. However, the lack of standardization in the usage of …

Since their initial discovery over a century ago, our knowledge of the functions of myoglobin
and the mitochondrion has gradually evolved. The mitochondrion, once thought to be solely …

Peroxisome proliferator-activated receptor α (PPARα) is a therapeutic target for
hyperlipidemia. Pemafibrate (K-877) is a new selective PPARα modulator activating PPARα …

Cytokines such as IL-6, TNF-α and IL-1β trigger inflammatory cascades which may play a
role in the pathogenesis of chronic kidney disease (CKD)-associated cachexia. CKD was …