Reactive oxygen species (ROS) play a critical role in defining the functional competence of
human spermatozoa. When generated in moderate amounts, ROS promote sperm …

Obesity is a risk factor for estrogen receptor-positive (ER+) breast cancer after menopause.
The pro-proliferative effects of estrogens are well characterized and there is a growing body …

Obesity has been recognized to increase the risk of such diseases as cardiovascular
diseases, diabetes, and cancer. It indicates that obesity can impact genome stability …

Oxidative stress plays an important role in cancer development and treatment. Recent data
implicate the tumor suppressor BRCA1 in regulating oxidative stress, but the molecular …

This is an overview of the metabolic activation of drugs, natural products, physiological
compounds, and general chemicals by the catalytic activity of cytochrome P450 enzymes …

Breast cancer is the most common female malignancy and the second leading cause of
cancer related deaths. It is estimated that about 40% of all cancer in women is hormonally …

Obesity is an established risk factor for breast cancer growth and progression. A number of
advances have been made in recent years revealing new insights into this link. Early events …

Breast cancer (BC) is the leading cause of cancer death in women. This disease is
heterogeneous, with clinical subtypes being estrogen receptor-α (ER-α) positive, having …

The mycotoxin alternariol (AOH) is produced by Alternaria fungi. It occurs naturally in
foodstuffs and is frequently found as contaminant in fruit and grain products. Most …

Background: Endocrine-disrupting chemicals have been shown to have broad effects on
development, but their mutagenic actions that can lead to cancer have been less clearly …