Immunotherapies play critical roles in cancer treatment. However, given that only a few
patients respond to immune checkpoint blockades and other immunotherapeutic strategies …

Inflammation is intimately involved at all stages of atherosclerosis and remains a substantial
residual cardiovascular risk factor in optimally treated patients. The proof of concept that …

The complex relationship between metabolic disease risk and body fat distribution in
humans involves cellular characteristics that are specific to body fat compartments. Here we …

We elucidated the molecular cross-talk between cartilage and synovium in osteoarthritis, the
most widespread arthritis in the world, using the powerful tool of single-cell RNA …

Rapid cost drops and advancements in next-generation sequencing have made profiling of
cells at individual level a conventional practice in scientific laboratories worldwide. Single …

Advances in transcriptome sequencing allow for simultaneous interrogation of differentially
expressed genes from multiple species originating from a single RNA sample, termed dual …

Background Lung adenocarcinoma (LUAD) patients with different American Joint Committee
on Cancer stages have different overall 5‐year survival rates. The tumor microenvironment …

Background The tumour heterogeneous make-up of immune cell infiltrates is a key factor for
the therapy response and prognosis of hepatocellular carcinoma (HCC). However, it is still a …

Quantitative traits are often complex because of the contribution of many loci, with further
complexity added by environmental factors. In medical research, systems genetics is a …

The lung tumor microenvironment, which is composed of heterogeneous cell populations,
plays an important role in the progression of lung cancer and is closely related to therapeutic …