Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

Abstract Purpose of Review We review recent developments on risk factors in
schizophrenia. Recent Findings The way we think about schizophrenia today is profoundly …

Psychosis is a heterogeneous psychiatric condition for which a multitude of risk and
protective factors have been suggested. This umbrella review aimed to classify the strength …

Cannabis use has been reported to induce long-lasting psychotic disorders and a dose-
response relationship has been observed. We performed a systematic review of studies that …

During the last years, an extraordinary effort has been made to identify biomarkers as
potential tools for improving prevention, diagnosis, drug response and drug development in …

The dopamine hypothesis is the longest standing pathoetiologic theory of schizophrenia.
Because it was initially based on indirect evidence and findings in patients with established …

Importance The developmental origins of mental illness are incompletely understood.
Although the development of autism and schizophrenia are linked to infections during fetal …

BackgroundSubjects at ultra high-risk (UHR) for psychosis have an enhanced vulnerability
to develop the disorder but the risk factors accounting for this accrued risk are undetermined …

Psychotic syndromes can be understood as disorders of adaptation to social context.
Although heritability is often emphasized, onset is associated with environmental factors …

Importance Mood disorders frequently co-occur with medical diseases that involve
inflammatory pathophysiologic mechanisms. Immune responses can affect the brain and …