The accumulation of pathological misfolded tau is a feature common to a collective of
neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is …

Most neurodegenerative disorders are associated with aggregated protein deposits. In the
case of Alzheimer disease (AD), extracellular amyloid-β (Aβ) aggregates and intracellular …

Purpose Tau deposition is a key pathological feature of Alzheimer's disease (AD) and other
neurodegenerative disorders. The spreading of tau neurofibrillary tangles across defined …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and a major
contributor to dementia cases worldwide. AD is clinically characterized by learning, memory …

The advent of tau-targeted PET tracers such as flortaucipir (18F)(flortaucipir, also known as
18F-AV-1451 or 18F-T807) have made it possible to investigate the sequence of …

The advent of PET ligands that bind tau pathology has enabled the quantification and
visualization of tau pathology in aging and in Alzheimer disease (AD). There is strong …

The development of tau-PET allows paired helical filament tau pathology to be visualized in
vivo. Increased knowledge about conditions affecting the rate of tau accumulation could …

The accumulation of amyloid fibrils is characteristic of neurodegenerative diseases such as
Alzheimer's disease (AD) and Parkinson's disease. Detecting these fibrils with fluorescent or …

Alzheimer's Disease (AD), the leading cause of senile dementia, is a progressive
neurodegenerative disorder affecting millions of people worldwide and exerting tremendous …

Abstract Objective Neurofibrillary tangles (NFTs), consisting of intracellular aggregates of the
tau protein, are a pathological hallmark of Alzheimer's disease (AD). Here we report the …