Heterotrimeric G proteins in vertebrates constitute a family molecular switches that transduce
the activation of a populous group of cell-surface receptors to a group of diverse effector …

One of the most intellectually challenging, scientifically productive, and socially applicable
endeavors of modern biological science is the current effort to understand the function of …

α-Synuclein has been implicated in the pathophysiology of many neurodegenerative
diseases, including Parkinson's disease (PD) and Alzheimer's disease. Mutations in α …

Transcription factor NF-E2-related factor 2 (Nrf2) regulates the induction of antioxidative
proteins, including heme oxygenase-1 (HO-1). Nrf2 is sequestered in the cytoplasm by …

Prostate cancer (PCa) is the second leading cause of cancer-related deaths in men.
Hormone-refractory invasive PCa is the end stage and accounts for the majority of PCa …

Free radicals and reactive oxygen species (ROS) are involved in a variety of different
cellular processes ranging from apoptosis and necrosis to cell proliferation and …

Background and Purpose—Stroke is a leading cause of disability and death in the United
States, yet limited therapeutic options exist. The need for novel neuroprotective agents has …

Although oxidant generation by NADPH oxidase is known to play an important role in
signaling in endothelial cells, the basis of activation of NADPH oxidase is incompletely …

Intracellular signaling mechanisms in red blood cells (RBCs) involve various protein kinases
and phosphatases and enable rapid adaptive responses to hypoxia, metabolic …

Oxidative stress is implicated in the nerve cell death that occurs in a variety of neurological
disorders, and the loss of protein kinase C (PKC) activity has been coupled to the severity of …