The oldest known highly conserved modification of RNA, N4-acetylcytidine, is widely
distributed from archaea to eukaryotes and acts as a posttranscriptional chemical …

The geroscience hypothesis proposes that addressing the biology of aging could directly
prevent the onset or mitigate the severity of multiple chronic diseases. Understanding the …

Polymyalgia rheumatica is one of the most common inflammatory rheumatic conditions in
older adults. The disease is characterized by pain and stiffness in the shoulder and pelvic …

Pancreatic ductal adenocarcinoma (PDAC) features an immunosuppressive tumor
microenvironment (TME) that resists immunotherapy. Tumor-associated macrophages …

Cellular senescence is a state of permanent growth arrest. It can be triggered by telomere
shortening (replicative senescence) or prematurely induced by stresses such as DNA …

Influenza virus outbreaks are a major burden worldwide each year. Current vaccination
strategies are inadequate due to antigenic drift/shift of the virus and the elicitation of low …

Salivary gland hypofunction is highly prevalent in aged and diseased individuals leading to
significant discomfort and morbidity. One factor that contributes to salivary gland …

During the early stages of limb and fin regeneration in aquatic vertebrates (ie, fishes and
amphibians), blastema undergo transcriptional rewiring of innate immune signaling …

Even if the SARS-CoV-2 pandemic has been declared over, several risks and clinical
problems remain to be faced, including long-COVID sequelae and possible outbreaks of …

Cellular senescence is a pivotal factor contributing to aging and the pathophysiology of age-
related diseases. Despite the presence of inflammation and abnormal immune system …