All patients with asthma are at risk of having exacerbations. Hospitalizations and emergency
department (ED) visits account for a large proportion of the health-care cost burden of …

Severe asthma, although difficult to define, includes all cases of difficult/therapy-resistant
disease of all age groups and bears the largest part of morbidity and mortality from asthma …

Objective To review the literature to determine the benefits of corticosteroids (CCSs)(oral, IM,
IV, or inhaled) in the treatment of adult patients with acute asthma presenting at an acute …

Rationale: Several studies published in the second half of the 1990s have shown a
therapeutic early effect of inhaled corticosteroids in acute asthma. However, systemic …

Diurnal-nocturnal, or circadian-like, rhythms are 24-h variations in biological processes,
evolved for the efficient functioning of living organisms. Such oscillations and their regulation …

Background The additive benefit of inhaled corticosteroid when used with systemic
corticosteroid in acute asthma is still unclear. The objective of this study was to assess the …

The precise definition of a severe asthmatic exacerbation is an issue that presents
difficulties. The term 'status asthmaticus' relates severity to outcome and has been used to …

BACKGROUND. Inhaled corticosteroids are not as effective as oral corticosteroids in school-
aged children with severe acute asthma. It is uncertain how inhaled corticosteroids compare …

The use of systemic corticosteroids, together with bronchodilators and oxygen therapy, has
become established for the management of acute asthma. These agents are undoubtedly …

The objective of the present study was to investigate the kinetics of high doses of inhaled
steroid fluticasone in comparison with oral steroid prednisone on plasma protein leakage …