[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene

S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …

[HTML][HTML] Daring to dream: Targeting lipoprotein (a) as a causal and risk-enhancing factor

ML Koschinsky, ESG Stroes, F Kronenberg - Pharmacological Research, 2023 - Elsevier
Abstract Lipoprotein (a)[Lp (a)], a distinct lipoprotein class, has become a major focus for
cardiovascular research. This review is written in light of the recent guideline and consensus …

Lp (a) lipoprotein in cardiovascular disease

GH Dahlén - Atherosclerosis, 1994 - Elsevier
The article summarizes the increased knowledge about the enigmatic Lp (a) lipoprotein and
its clinical importance over the past 20 years. The mode of inheritance, the unique features …

CETP (cholesteryl ester transfer protein) inhibition with anacetrapib decreases production of lipoprotein (a) in mildly hypercholesterolemic subjects

T Thomas, H Zhou, W Karmally… - … , and vascular biology, 2017 - Am Heart Assoc
Objective—Lp (a)[lipoprotein (a)] is composed of apoB (apolipoprotein B) and apo
(a)[apolipoprotein (a)] and is an independent risk factor for cardiovascular disease and …

A novel but frequent variant in LPA KIV-2 is associated with a pronounced Lp(a) and cardiovascular risk reduction

S Coassin, G Erhart, H Weissensteiner… - European heart …, 2017 - academic.oup.com
Aims Lp (a) concentrations represent a major cardiovascular risk factor and are almost
entirely controlled by one single locus (LPA). However, many genetic factors in LPA …

Frequency distributions of apolipoprotein (a) kringle IV repeat alleles and their effects on lipoprotein (a) levels in Caucasian, Asian, and African populations: the …

HG Kraft, A Lingenhel, RWC Pang, R Delport… - European Journal of …, 1996 - nature.com
Abstract A size polymorphism (K IV VNTR) and largely unknown sequence variation in the
apolipoprotein (a)[apo (a)] gene on chromosome 6q26–q27 together determine most of the …

Variation at the hepatic lipase and apolipoprotein AI/CIII/AIV loci is a major cause of genetically determined variation in plasma HDL cholesterol levels.

JC Cohen, Z Wang, SM Grundy… - The Journal of …, 1994 - Am Soc Clin Investig
Genetic factors have been shown to play an important role in determining interindividual
variation in plasma HDL-C levels, but the specific genetic determinants of HDL cholesterol …

Advantages and limitations of nonhuman primates as animal models in genetic research on complex diseases

JL VandeBerg… - Journal of medical …, 1997 - Wiley Online Library
The genetic similarity between humans and nonhuman primates makes nonhuman primates
uniquely suited as models for genetic research on complex physiological and behavioral …

Variation in lipoprotein (a) concentration associated with different apolipoprotein (a) alleles.

YF Perombelon, AK Soutar… - The Journal of clinical …, 1994 - Am Soc Clin Investig
Plasma lipoprotein (a)(Lp (a)) concentrations vary considerably between individuals. To
examine the variation for products of the same and different apolipoprotein (a)(apo (a)) …

[HTML][HTML] Monogenic dyslipidemias: window on determinants of plasma lipoprotein metabolism

RA Hegele - The American Journal of Human Genetics, 2001 - cell.com
). Genetic susceptibility plays a key role in atherosclerosis, particularly when clinical end
points strike early in life. Some risk factors—such as dyslipidemia, diabetes and …