Interleukin-23 (IL-23) is a proinflammatory cytokine produced mainly by macrophages and
antigen-presenting cells (APCs) after antigenic stimulation. IL-23 plays a significant role as a …

Cytokines bind to specific receptors on target cells to activate intracellular signaling
pathways that control diverse cellular functions, such as proliferation, differentiation …

Mirikizumab (Omvoh®), a humanized IgG4 anti-human IL-23p19 monoclonal antibody, is
being developed by Eli Lilly and Company Ltd for the treatment of ulcerative colitis and …

Psoriasis is an enduring, pruritic and papulosquamous skin ailment that poses a significant
burden on public health. It is mainly characterized by hyperkeratosis, acanthosis …

Curcumin (Cur) is a natural active phenolic compound extracted from the root of Curcuma
Longa L. It has anti‐inflammatory, anti‐tumor and other pharmacological activities, and is …

Background: Inflammatory bowel diseases (IBDs) are chronic, recurrent inflammatory
diseases with partly understood etiology and pathogenesis. The course of IBD, both …

Inflammatory bowel disease (IBD) is a lifelong inflammatory immune mediated disorder,
encompassing Crohn's disease (CD) and ulcerative colitis (UC); however, the cause and …

Inflammatory bowel disease (IBD) is a chronic relapsing-remitting inflammatory disease of
the gastrointestinal tract. Patients are usually diagnosed in adolescence and early …

Abstract Treatment strategies for inflammatory bowel disease (IBD) are rapidly evolving with
the development of biologics and small molecule drugs (SMDs). However, these drugs are …

A member of the interleukin (IL)-1 superfamily was IL-36, which contained IL-36α, IL-36β, IL-
36γ, and IL-36Ra. Heterotrimer complexes, consisting of heterodimeric receptor complexes …