Since dacarbazine was approved for treating metastatic melanoma in the 1970s, numerous
studies have evaluated whether different schedules and dacarbazine-based combinations …

Summation Cancer immunotherapy consists of approaches that modify the host immune
system, and/or the utilization of components of the immune system, as cancer treatment …

The incidence of cutaneous melanoma has been rapidly increasing, with an estimate of
47,700 new cases diagnosed in 2000 in the United States. In the early phase of its natural …

A wide variety of tumor cells exhibit overexpression of urokinase plasminogen activator
(uPA) and its receptor (uPAR). In breast cancer, expression of uPA and uPAR is essential for …

The purpose of this randomized trial was to evaluate the efficacy of combination
chemoimmunotherapy compared with chemotherapy alone. A total of 124 patients were …

Global importance: The two feline retroviruses, feline immunodeficiency virus (FIV) and
feline leukaemia virus (FeLV), are global and widespread, but differ in their potential to …

Interferons (IFNs) represent an important defense mechanism in vertebrates. In this work, we
describe gene synthesis and assembly using the polymerase chain reaction as a method for …

The classical model of cytokine signaling dominates our view of specific gene activation by
cytokines such as the interferons (IFNs). The importance of the model extends beyond …

Feline immunodeficiency virus (FIV) is one of the most common infectious agents affecting
cats worldwide. FIV and human immunodeficiency virus (HIV) share many properties: both …

Abstract Interferon-α2b (IFN-α2b) is a highly active cytokine that belongs to the interferon-α
(IFN-α) family. IFN-α2b has beneficial antiviral, antitumour, antiparasitic and …