[PDF][PDF] Synthetic yeast chromosome XI design provides a testbed for the study of extrachromosomal circular DNA dynamics
BA Blount, X Lu, MRM Driessen, D Jovicevic… - Cell Genomics, 2023 - cell.com
We describe construction of the synthetic yeast chromosome XI (synXI) and reveal the
effects of redesign at non-coding DNA elements. The 660-kb synthetic yeast genome project …
effects of redesign at non-coding DNA elements. The 660-kb synthetic yeast genome project …
Precise detection of de novo single nucleotide variants in human genomes
L Gómez-Romero, K Palacios-Flores… - Proceedings of the …, 2018 - National Acad Sciences
The precise determination of de novo genetic variants has enormous implications across
different fields of biology and medicine, particularly personalized medicine. Currently, de …
different fields of biology and medicine, particularly personalized medicine. Currently, de …
Synthetic yeast chromosome XI design enables extrachromosomal circular DNA formation on demand
BA Blount, X Lu, MRM Driessen, D Jovicevic… - bioRxiv, 2022 - biorxiv.org
We describe construction of the 660 kilobase synthetic yeast chromosome XI (synXI) and
reveal how synthetic redesign of non-coding DNA elements impact the cell. To aid …
reveal how synthetic redesign of non-coding DNA elements impact the cell. To aid …
Perfect Match Genomic Landscape strategy: Refinement and customization of reference genomes
K Palacios-Flores, J García-Sotelo… - Proceedings of the …, 2021 - National Acad Sciences
When addressing a genomic question, having a reliable and adequate reference genome is
of utmost importance. This drives the necessity to refine and customize reference genomes …
of utmost importance. This drives the necessity to refine and customize reference genomes …
Prediction and identification of recurrent genomic rearrangements that generate chimeric chromosomes in Saccharomyces cerevisiae
K Palacios-Flores, A Castillo, C Uribe… - Proceedings of the …, 2019 - National Acad Sciences
Genomes are dynamic structures. Different mechanisms participate in the generation of
genomic rearrangements. One of them is nonallelic homologous recombination (NAHR) …
genomic rearrangements. One of them is nonallelic homologous recombination (NAHR) …