Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …

During placentation invasive extravillous trophoblasts (EVTs) migrate into the maternal
uterus and modify its vessels. In particular, remodeling of the spiral arteries by EVTs is …

An improved mechanistic understanding of the adaptational processes mounted during
mammalian reproduction is emerging. Intricate pathways occurring at the fetomaternal …

Human CD56bright NK cells accumulate in the maternal decidua during pregnancy and are
found in direct contact with fetal trophoblasts. Several mechanisms have been proposed to …

Successful pregnancy in placental mammals substantially depends on the establishment of
maternal immune tolerance to the semi-allogenic fetus. Disorders in this process are tightly …

BACKGROUND Recurrent miscarriage and pre-eclampsia are common reproductive
disorders, but their causes are often unknown. Recent evidence has provided new insight …

Cellular senescence is a stress response mechanism that limits tumorigenesis and tissue
damage. Induction of cellular senescence commonly coincides with an immunogenic …

Malignant cells from at least 23 different types of cancer express the chemokine receptor
CXCR4 and respond to its ligand CXCL12. This receptor ligand pair appears to be involved …

Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the
earliest arrivals at target organs of disease. However, the role of NK cells in mounting …

Deficiency in decidualization has been widely regarded as an important cause of
spontaneous abortion. Generalized decidualization also includes massive infiltration and …