The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy
Cancer remains as one of the most significant health problems, with approximately 19
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …
Targeting tumor microenvironment for cancer therapy
C Roma-Rodrigues, R Mendes, PV Baptista… - International journal of …, 2019 - mdpi.com
Cancer development is highly associated to the physiological state of the tumor
microenvironment (TME). Despite the existing heterogeneity of tumors from the same or from …
microenvironment (TME). Despite the existing heterogeneity of tumors from the same or from …
Clinical implications of intratumor heterogeneity: challenges and opportunities
S Ramón y Cajal, M Sesé, C Capdevila… - Journal of Molecular …, 2020 - Springer
In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and
biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through …
biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through …
Extracellular vesicle heterogeneity: subpopulations, isolation techniques, and diverse functions in cancer progression
Cells release membrane enclosed nano-sized vesicles termed extracellular vesicles (EVs)
that function as mediators of intercellular communication by transferring biological …
that function as mediators of intercellular communication by transferring biological …
Cell culture in microfluidic droplets
Cell manipulation in droplets has emerged as one of the great successes of microfluidic
technologies, with the development of single-cell screening. However, the droplet format has …
technologies, with the development of single-cell screening. However, the droplet format has …
Epithelial‐to‐mesenchymal transition in oral squamous cell carcinoma: challenges and opportunities
Z Ling, B Cheng, X Tao - International journal of cancer, 2021 - Wiley Online Library
Oral squamous cell carcinoma (OSCC) is the most common malignancy representing 90%
of all forms of oral cancer worldwide. Although great efforts have been made in the past …
of all forms of oral cancer worldwide. Although great efforts have been made in the past …
Roles of circRNAs in the tumour microenvironment
Q Zhang, W Wang, Q Zhou, C Chen, W Yuan, J Liu… - Molecular cancer, 2020 - Springer
The tumour microenvironment (TME) constitutes the area surrounding the tumour during its
development and has been demonstrated to play roles in cancer-related diseases through …
development and has been demonstrated to play roles in cancer-related diseases through …
Organoid models of gastrointestinal cancers in basic and translational research
Cancer is a major public health problem worldwide. Gastrointestinal cancers account for
approximately one-third of the total global cancer incidence and mortality. Historically, the …
approximately one-third of the total global cancer incidence and mortality. Historically, the …
Combinatorial therapy in tumor microenvironment: where do we stand?
The tumor microenvironment plays a pivotal role in tumor initiation and progression by
creating a dynamic interaction with cancer cells. The tumor microenvironment consists of …
creating a dynamic interaction with cancer cells. The tumor microenvironment consists of …
Omentum-on-a-chip: A multicellular, vascularized microfluidic model of the human peritoneum for the study of ovarian cancer metastases
Epithelial ovarian cancer has the highest mortality rate of any gynecologic malignancy and
most frequently metastasizes to the peritoneal cavity. Intraperitoneal metastases are highly …
most frequently metastasizes to the peritoneal cavity. Intraperitoneal metastases are highly …