The field of research in bladder cancer has seen significant advances in recent years. Next-
generation sequencing has identified the genes most mutated in bladder cancer. This …

Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

Trimethylation of histone H3 lysine 4 (H3K4me3) is associated with transcriptional start sites
and has been proposed to regulate transcription initiation,. However, redundant functions of …

Since the first half of the twentieth century, evolutionary theory has been dominated by the
idea that mutations occur randomly with respect to their consequences. Here we test this …

Recent advances in cancer characterization have consistently revealed marked
heterogeneity, impeding the completion of integrated molecular and clinical maps for each …

The regulated transcription of genes determines cell identity and function. Recent structural
studies have elucidated mechanisms that govern the regulation of transcription by RNA …

The epigenetic modifications of histones are versatile marks that are intimately connected to
development and disease pathogenesis including human cancers. In this review, we will …

Abstract The Trithorax group (TrxG) of proteins is a large family of epigenetic regulators that
form multiprotein complexes to counteract repressive developmental gene expression …

The genetic compensation response (GCR) has recently been proposed as a possible
explanation for the phenotypic discrepancies between gene-knockout and gene …

Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …