Inert and stable radiolabeling of monoclonal antibodies (mAb), antibody fragments, or
antibody mimetics with radiometals is a prerequisite for immuno-PET. While radiolabeling is …

Immuno-positron emission tomography (immunoPET) imaging is a paradigm-shifting
imaging technique for whole-body and all-lesion tumor detection, based on the combined …

Conspectus Molecular imaging with antibodies radiolabeled with positron-emitting
radionuclides combines the affinity and selectivity of antibodies with the sensitivity of …

Desferoxamine (DFO) is currently the golden standard chelator for 89 Zr 4+, a promising
nuclide for positron emission tomography imaging (PET). The natural siderophore DFO had …

Cell death is fundamental in health and disease and resisting cell death is a hallmark of
cancer. Treatment of malignancy aims to cause cancer cell death, however current clinical …

Herein, we report the synthesis of three new bifunctional heptadentate metal ion binding
chelates derived from desferrioxamine B (DFO) linked to a tripeptide unit that comprises of a …

Zirconium is a highly demanded element widely used in various fields of science and
technology. There are 39 known zirconium isotopes, among which zirconium-89 (T 1/2 …

The key factors participating in angiogenesis include vascular endothelial growth factor
(VEGF) and its receptors (VEGFRs), particularly VEGFR2. Angiogenesis suppression …

Background Platinum‐based chemotherapy and radiotherapy are standard treatments for
non‐small cell lung cancer, which is the commonest, most lethal cancer worldwide. As a …

Purpose Early detection of tumor treatment responses represents an unmet clinical need
with no approved noninvasive methods. DAB4, or its chimeric derivative, chDAB4 …