Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Despite recent advances in the management of chronic kidney disease (CKD), morbidity
and mortality rates in these patients remain high. While pressure-mediated injury is a well …

The pathogenetic mechanisms underlying the onset and the post-transplant recurrence of
primary focal segmental glomerulosclerosis (FSGS) are complex and remain yet to be fully …

Alport syndrome (AS) is a hereditary kidney disease associated with proteinuria, hematuria
and progressive kidney failure. It is characterized by a defective glomerular basement …

Introduction: Alport syndrome is a rare genetic disorder that affects as many as 60,000
persons in the USA and a total of 103,000 persons (< 5 per 10,000) in the European Union …

Introduction: Chronic kidney disease (CKD) is a major public health issue in the USA.
Identification of monogenic causes of CKD, which are present in∼ 10% of adult cases, can …

Background Genetic testing in CKD has recently been shown to have diagnostic utility with
many predicted implications for clinical management, but its effect on management has not …

The basement membrane (BM) is a specialized layer of extracellular matrix components that
plays a central role in maintaining lung and kidney functions. Although the composition of …

Alport Syndrome - StatPearls - NCBI Bookshelf US flag An official website of the United
States government Here's how you know NIH NLM Logo Access keys NCBI Homepage …

Kidney disease is a global health and healthcare burden. Glomerulonephritis (Gn), both
primary and secondary, is generally characterized by an inflammatory glomerular injury and …