Air-Liquid interface cultures to model drug delivery through the mucociliary epithelial barrier

RE Lee, B Reidel, MR Nelson, JK Macdonald… - Advanced Drug Delivery …, 2023 - Elsevier
Epithelial cells from mucociliary portions of the airways can be readily grown and expanded
in vitro. When grown on a porous membrane at an air–liquid interface (ALI) the cells form a …

Microfluidic chip as a promising evaluation method in assisted reproduction: A systematic review

T Wu, Y Wu, J Yan, J Zhang… - … & Translational Medicine, 2024 - Wiley Online Library
The aim of assisted reproductive technology (ART) is to select the high‐quality sperm,
oocytes, and embryos, and finally achieve a successful pregnancy. However, functional …

Material properties of nonpregnant and pregnant human uterine layers

DM Fodera, SR Russell, JLL Jackson, S Fang… - Journal of the …, 2024 - Elsevier
The uterus has critical biomechanical functions in pregnancy and undergoes dramatic
material growth and remodeling from implantation to parturition. The intrinsic material …

Report of the assay guidance workshop on 3-dimensional tissue models for antiviral drug development

R Jordan, SL Ford-Scheimer… - The Journal of …, 2023 - academic.oup.com
Abstract The National Center for Advancing Translational Sciences (NCATS) Assay
Guidance Manual (AGM) Workshop on 3D Tissue Models for Antiviral Drug Development …

Advanced Technologies for Studying Microbiome–Female Reproductive Tract Interactions: Organoids, Organoids-on-a-Chip, and Beyond

YA Kaya, MR de Zoete, GS Steba - Seminars in reproductive …, 2024 - thieme-connect.com
The female reproductive tract (FRT) is home to diverse microbial communities that play a
pivotal role in reproductive health and disorders such as infertility, endometriosis, and …

[HTML][HTML] Notoginsenoside R1 promotes Lgr5+ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling

Z Yu, R Gao, C Lv, X Geng, Y Ren, J Zhang… - Acta Pharmacologica …, 2024 - nature.com
Inflammatory bowel disease (IBD) is characterized by persistent damage to the intestinal
barrier and excessive inflammation, leading to increased intestinal permeability. Current …

[HTML][HTML] Hydrogel-Integrated Millifluidic Systems: Advancing the Fabrication of Mucus-Producing Human Intestinal Models

A Almalla, N Alzain, L Elomaa, F Richter, J Scholz… - Cells, 2024 - mdpi.com
The luminal surface of the intestinal epithelium is protected by a vital mucus layer, which is
essential for lubrication, hydration, and fostering symbiotic bacterial relationships …

Mucus‐Mimicking Mucin‐Based Hydrogels by Tandem Chemical and Physical Crosslinking

NN Porfiryeva, I Zlotver… - Macromolecular …, 2024 - Wiley Online Library
Mucosal tissues represent a major interface between the body and the external environment
and are covered by a highly hydrated mucins gel called mucus. Mucus lubricates, protects …

Tumour organoids and assembloids: Patient‐derived cancer avatars for immunotherapy

J Mei, X Liu, HX Tian, Y Chen, Y Cao… - Clinical and …, 2024 - Wiley Online Library
Background Organoid technology is an emerging and rapidly growing field that shows
promise in studying organ development and screening therapeutic regimens. Although …

[HTML][HTML] Advances in the Evaluation of Gastrointestinal Absorption Considering the Mucus Layer

K Miyazaki, A Sasaki, H Mizuuchi - Pharmaceutics, 2023 - mdpi.com
Because of the increasing sophistication of formulation technology and the increasing
polymerization of compounds directed toward undruggable drug targets, the influence of the …