Arrhythmogenic right ventricular cardiomyopathy

D Corrado, MS Link, H Calkins - New England journal of …, 2017 - Mass Medical Soc
Arrhythmogenic right ventricular cardiomyopathy is a heritable heart-muscle disorder that
causes progressive replacement of right ventricular myocardium by fibrofatty tissue …

Are there deleterious cardiac effects of acute and chronic endurance exercise?

TMH Eijsvogels, AB Fernandez… - Physiological …, 2016 - journals.physiology.org
Multiple epidemiological studies document that habitual physical activity reduces the risk of
atherosclerotic cardiovascular disease (ASCVD), and most demonstrate progressively lower …

Molecular mechanisms of arrhythmogenic cardiomyopathy

KM Austin, MA Trembley, SF Chandler… - Nature Reviews …, 2019 - nature.com
Arrhythmogenic cardiomyopathy is a genetic disorder characterized by the risk of life-
threatening arrhythmias, myocardial dysfunction and fibrofatty replacement of myocardial …

Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the task force criteria

FI Marcus, WJ McKenna, D Sherrill, C Basso, B Bauce… - Circulation, 2010 - Am Heart Assoc
Background—In 1994, an International Task Force proposed criteria for the clinical
diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) that …

Distinguishing arrhythmogenic right ventricular cardiomyopathy/dysplasia–associated mutations from background genetic noise

JD Kapplinger, AP Landstrom, BA Salisbury… - Journal of the American …, 2011 - jacc.org
Objectives: The aims of this study were to determine the spectrum and prevalence of
“background genetic noise” in the arrhythmogenic right ventricular cardiomyopathy …

Ablation of ventricular arrhythmias in arrhythmogenic right ventricular dysplasia/cardiomyopathy: arrhythmia-free survival after endo-epicardial substrate based …

R Bai, L Di Biase, K Shivkumar, P Mohanty… - Circulation …, 2011 - Am Heart Assoc
Background—In patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy,
freedom from ventricular arrhythmias (VAs) after endocardial ablation is limited. We …

Plakophilin 2 gene therapy prevents and rescues arrhythmogenic right ventricular cardiomyopathy in a mouse model harboring patient genetics

WH Bradford, J Zhang, EJ Gutierrez-Lara… - Nature Cardiovascular …, 2023 - nature.com
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a fatal genetic heart disease
characterized by cardiac arrhythmias, in which fibrofatty deposition leads to heart failure …

De novo desmin-mutation N116S is associated with arrhythmogenic right ventricular cardiomyopathy

B Klauke, S Kossmann, A Gaertner… - Human molecular …, 2010 - academic.oup.com
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle
disease, frequently accompanied by sudden cardiac death and terminal heart failure …

Arrhythmogenic right ventricular cardiomyopathy/dysplasia: a review and update

A Azaouagh, S Churzidse, T Konorza… - Clinical research in …, 2011 - Springer
Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is a predominantly
genetically determined and heritable form of cardiomyopathy that is characterized …

Cardiac cell–cell junctions in health and disease: electrical versus mechanical coupling

M Noorman, MAG van der Heyden… - Journal of molecular and …, 2009 - Elsevier
Intercalated discs are the membrane sites where individual cardiomyocytes are connected
to each other. Adherens-, desmosomal-, and gap junctions are situated in the intercalated …