Lung cancer remains the leading cause of cancer-related deaths worldwide. β-arrestin-1
(ARRB1), a scaffolding protein involved in the desensitization of signals arising from …

Objectives Given our previously published study, α 1 nicotinic acetylcholine receptor
(nAChR) plays an essential role in nicotine-induced cell signaling and nicotine-induced …

Abstract Human Ly-6/uPAR-related protein-1 (SLURP-1) is an allosteric negative modulator
of the α7-type nicotinic acetylcholine receptor (α7-nAChR), one of the key receptors …

After more than a decade of extensive experimentation, the promise of stem cells to
revolutionize the field of medicine has negotiated their entry into clinical trial. Adipose tissue …

Oral cancer and smoking are closely related, because the oral cavity, which is the route of
ingestion of tobacco smoke, is in direct contact with the oral mucosa. Nicotine, one of the …

Nicotine is the major addictive component of cigarette smoke and although it is not
considered carcinogenic, it can enhance or inhibit cancer cell proliferation depending on the …

Electronic cigarettes have become a purported safer alternative to the conventional
cigarettes in recent years. Nicotine is the main component of electronic cigarettes, and other …

Objectives Nicotine and its associated nicotinic acetylcholine receptors (nAChRs) are
believed to be involved in the progression of lung carcinomas. This study aimed at …

Epidemiological studies suggest that lung cancer, which is a major cause of cancer death,
has a critical association with cigarette smoking. Tobacco-specific nitrosamine 4 …

Growth factors and COX-2/PGE2 enhance lung cancer invasion/metastasis via PI3K/Akt and
RAS/Raf. Here, we explored their mechanism of action further. We found first that higher …