Objectives Nicotine and its associated nicotinic acetylcholine receptors (nAChRs) are
believed to be involved in the progression of lung carcinomas. This study aimed at …

Lung cancers express non-neuronal, cholinergic autoparacrine loop, which facilitates tumor
growth. Interruption of M3 muscarinic cholinergic signaling has been reported to inhibit small …

Growth factors and COX-2/PGE2 enhance lung cancer invasion/metastasis via PI3K/Akt and
RAS/Raf. Here, we explored their mechanism of action further. We found first that higher …

AIM: To investigate the contribution of periostin in nicotine-promoted gastric cancer cell
proliferation, survival, invasion, drug resistance, and epithelial-mesenchymal transition …

Promoting smoking cessation is among the key medical interventions aimed at reducing
worldwide morbidity and mortality in this century. Both behavioural counselling and …

Non-neuronal cholinergic system is involved in lung physiology and lung cancer. However,
the biochemical events downstream acetylcholine (ACh) receptor activation leading to …

Cigarette smoke, specifically the nicotine contained within, has been shown to correlate
closely with cell invasion and strategies to downregulate their expression may ultimately be …

Lung cancer is the leading cause of cancer-related deaths worldwide. Smoking accounts for
approximately 70% of the cases of non–small cell lung cancer (NSCLC) and 90% of the …

The present study aimed to investigate the effect of glutathione S-transferase A1 (GSTA1) on
lung cancer cell viability, invasion and adhesion in the presence of nicotine in vitro …

Background Lung cancer is the leading cause of cancer-related deaths worldwide. Several
targets have been identified for lung cancer therapy, amongst which 'Microtubule'and its …