The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …

Adaptive immune responses mediated by T cells and B cells are crucial for protective
immunity against pathogens and tumors. Differentiation and function of immune cells require …

Metabolic adaptation to viral infections critically determines the course and manifestations of
disease. At the systemic level, a significant feature of viral infection and inflammation that …

T lymphocytes (T cells) are divided into two functionally different subgroups the CD4+ T
helper cells (Th) and the CD8+ cytotoxic T lymphocytes (CTL). Adequate CD4 and CD8 T …

Immunometabolism, which is the metabolic reprogramming of anaerobic glycolysis,
oxidative phosphorylation, and metabolite synthesis upon immune cell activation, has …

Macrophages are essential innate immune cells that contribute to host defense during
infection. An important feature of macrophages is their ability to respond to extracellular cues …

As modern biological sciences evolve from investigation of individual molecules and
pathways to growing emphasis on global and systems-based processes, increasing efforts …

Background: The term immunometabolism describes cellular and molecular metabolic
processes that control the immune system and the associated immune responses. Acute …

HIV‐1 infects lymphoid and myeloid cells, which can harbor a latent proviral reservoir
responsible for maintaining lifelong infection. Glycolytic metabolism has been identified as a …

We have previously demonstrated mitochondrial dysfunction in aging CD4 T cells from
antiretroviral therapy (ART)-controlled people living with HIV (PLWH). However, the …