Protein replacement therapy is an umbrella term used for medical treatments that aim to
substitute or replenish specific protein deficiencies that result either from the protein being …

Poly (A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called
cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has …

Understanding gene expression and regulation requires insights into RNA transcription,
processing, modification, and translation. However, the relationship between the …

We have purified and characterized a factor required for accurate polyadenylation of
mammalian pre-mRNAs in vitro. This factor, called cleavage-stimulation factor (CstF), is …

Biological polyadenylation, first recognized as an enzymatic activity, remained an orphan
enzyme until poly A sequences were found on the 3′ ends of eukaryotic mRNAs. Their …

Polyadenylation in the nucleus 1 and in a cell-free nuclear extract 2 immediately follows a
cleavage reaction in which a phosphodiester bond in the mRNA precursor is broken (Fig. 1) …

The human Ul snRNP-specific UlA protein autoregulates its production by binding its own
pre-mRNA and inhibiting polyadenylation. The mechanism of this regulation has been …

Molecular biotechnology has made it possible to explore the potential of plants for different
purposes. The 3'regulatory regions have a great diversity of cis-regulatory elements directly …

Cleavage-polyadenylation specificity factor (CPSF) is one of five separable factors known to
be required for 3 'cleavage and polyadenylation of mRNA precursors in vitro. Previous …

We have previously shown that the U1 snRNP-A protein (U1A) interacts with elements in
SV40 late polyadenylation signal and that this association increases polyadenylation …