The pharmacokinetics and the pharmacodynamics of cannabinoids

CJ Lucas, P Galettis, J Schneider - British journal of clinical …, 2018 - Wiley Online Library
There is increasing interest in the use of cannabinoids for disease and symptom
management, but limited information available regarding their pharmacokinetics and …

Cannabidiol adverse effects and toxicity

MA Huestis, R Solimini, S Pichini… - Current …, 2019 - ingentaconnect.com
Background: Currently, there is a great interest in the potential medical use of cannabidiol
(CBD), a non-intoxicating cannabinoid. Productive pharmacological research on CBD …

Practical considerations in medical cannabis administration and dosing

CA MacCallum, EB Russo - European journal of internal medicine, 2018 - Elsevier
Cannabis has been employed medicinally throughout history, but its recent legal prohibition,
biochemical complexity and variability, quality control issues, previous dearth of …

Potential adverse drug events and drug–drug interactions with medical and consumer cannabidiol (CBD) use

JD Brown, AG Winterstein - Journal of clinical medicine, 2019 - mdpi.com
Cannabidiol (CBD) is ubiquitous in state-based medical cannabis programs and consumer
products for complementary health or recreational use. CBD has intrinsic pharmacologic …

Cannabidiol: a potential new alternative for the treatment of anxiety, depression, and psychotic disorders

MS García-Gutiérrez, F Navarrete, A Gasparyan… - Biomolecules, 2020 - mdpi.com
The potential therapeutic use of some Cannabis sativa plant compounds has been attracting
great interest, especially for managing neuropsychiatric disorders due to the relative lack of …

Phytocannabinoids: a unified critical inventory

LO Hanuš, SM Meyer, E Muñoz… - Natural product …, 2016 - pubs.rsc.org
Covering up to January 2016 Cannabis sativa L. is a prolific, but not exclusive, producer of a
diverse group of isoprenylated resorcinyl polyketides collectively known as …

An update on safety and side effects of cannabidiol: a review of clinical data and relevant animal studies

K Iffland, F Grotenhermen - Cannabis and cannabinoid research, 2017 - liebertpub.com
Introduction: This literature survey aims to extend the comprehensive survey performed by
Bergamaschi et al. in 2011 on cannabidiol (CBD) safety and side effects. Apart from …

Molecular targets of the phytocannabinoids: a complex picture

P Morales, DP Hurst, PH Reggio - Phytocannabinoids: Unraveling the …, 2017 - Springer
For centuries, hashish and marihuana, both derived from the Indian hemp Cannabis sativa
L., have been used for their medicinal, as well as, their psychotropic effects. These effects …

A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain

CD Verrico, S Wesson, V Konduri, CJ Hofferek… - Pain, 2020 - journals.lww.com
1. Background Arthritis is a leading cause of pain, disfigurement, and disability in the United
States where nearly one-quarter of all adults have received an affirmative diagnosis. 2 …

[HTML][HTML] The molecular activity of cannabidiol in the regulation of Nrf2 system interacting with NF-κB pathway under oxidative stress

SA Ekiner, A Gęgotek, E Skrzydlewska - Redox Biology, 2022 - Elsevier
Cannabidiol (CBD), the major non-psychoactive phytocannabinoid of Cannabis sativa L., is
one of the most studied compounds in pharmacotherapeutic approaches to treat oxidative …