Anti-IL-1 treatment for secondary amyloidosis in an adolescent with FMF and Behçet's disease

Y Bilginer, NA Ayaz, S Ozen - Clinical rheumatology, 2010 - Springer
Familial Mediterranean fever (FMF) is associated with mutations in the gene coding for pyrin
which lead to accentuated innate immune responses resulting in increased production of IL …

[HTML][HTML] Update on the management of colchicine resistant Familial Mediterranean Fever (FMF)

G El Hasbani, A Jawad, I Uthman - Orphanet journal of rare diseases, 2019 - Springer
Abstract Background Familial Mediterranean Fever (FMF), an autoinflammatory disease, is
characterized by self-limited inflammatory attacks of fever and polyserositis along with high …

The clinical role of anakinra in the armamentarium against familial Mediterranean fever

K Parlar, MB Ates, BH Egeli… - Expert Review of Clinical …, 2024 - Taylor & Francis
ABSTRACT Introduction Familial Mediterranean Fever (FMF) is the most common
autoinflammatory disease that has mainly been treated with colchicine since 1972. A …

[PDF][PDF] Cutaneous amyloidoses and systemic amyloidoses with cutaneous involvement

S Schreml, RM Szeimies, T Vogt… - European Journal of …, 2010 - researchgate.net
Extracellular deposition of altered autologous protein (amyloid protein) within the dermis is
the hallmark of cutaneous amyloidoses and systemic amyloidoses with cutaneous …

[PDF][PDF] Therapeutic approach to familial Mediterranean fever: a review update

MA Ozturk, M Kanbay, B Kasapoglu… - Clin Exp …, 2011 - clinexprheumatol.org
Familial Mediterranean fever (FMF) is a hereditary disorder characterised by recurrent
attacks of fever with peritonitis or pleuritis, arthritis, myalgia or erysipelas-like skin lesions …

Inflammasome and cytokine blocking strategies in autoinflammatory disorders

M Moll, JB Kuemmerle-Deschner - Clinical immunology, 2013 - Elsevier
Autoinflammatory disorders are characterized by usually unprovoked recurrent episodes of
features of inflammation caused by activation of the innate immune system. Many …

Inflammasome-dependent cytokines at the crossroads of health and autoinflammatory disease

H Van Gorp, N Van Opdenbosch… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
As key regulators of both innate and adaptive immunity, it is unsurprising that the activity of
interleukin (IL)-1 cytokine family members is tightly controlled by decoy receptors …

Anti-IL1 treatment in colchicine-resistant paediatric FMF patients: real life data from the HELIOS registry

E Sag, F Akal, E Atalay, UK Akca, S Demir… - …, 2020 - academic.oup.com
Objectives FMF is a prototype of autoinflammatory diseases associated with excess IL1
production. Anti-IL1 treatments are the first-line alternatives in colchicine-resistant/intolerant …

Inflammasomes and rheumatic diseases: evolving concepts

PI Sidiropoulos, G Goulielmos… - Annals of the …, 2008 - ard.bmj.com
The realisation that the production of inflammatory cytokines in inflammatory rheumatic
diseases may be induced by non-infectious endogenous signals has encouraged …

[HTML][HTML] The central role of anti-IL-1 blockade in the treatment of monogenic and multi-factorial autoinflammatory diseases

S Federici, A Martini, M Gattorno - Frontiers in immunology, 2013 - frontiersin.org
Inherited autoinflammatory diseases are secondary to mutations of proteins playing a pivotal
role in the regulation of the innate immunity leading to seemingly unprovoked episodes of …