Schizophrenia remains a challenging disease to treat effectively with current antipsychotic
medications due to their limited efficacy across the entire spectrum of core symptoms as well …

Alzheimer's disease (AD) remains a major cause of morbidity and mortality worldwide, and
despite extensive research, only a few drugs are available for management of the disease …

Allosteric regulation is critical for the functioning of G protein-coupled receptors (GPCRs)
and their signaling pathways. Endogenous allosteric regulators of GPCRs are simple ions …

Introduction Successful phase 3 trials of KarXT in people with schizophrenia herald a new
era of treating the disorder with drugs that do not target the dopamine D2 receptor. The …

G-protein coupled receptors (GPCRs) are considered important therapeutic targets due to
their pathophysiological significance and pharmacological relevance. Class A receptors …

Muscarinic acetylcholine receptors are membrane receptors involved in many physiological
processes. Malfunction of muscarinic signaling is a cause of various internal diseases, as …

The muscarinic cholinergic system regulates peripheral and central nervous system
functions, and, thus, their potential as a therapeutic target for several neurodegenerative …

The parasympathetic nervous system is critically involved in the regulation of tear secretion
by activating muscarinic acetylcholine receptors. Hence, various animal models targeting …

We investigated the genome of a 5-year-old male who presented with global developmental
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …

It was a pleasure to receive a proposal to organize and be a guest editor of a Special Issue
of Biomolecules. This is the field in which I am working and personally know some of the …