Genetic variability in humans is influenced by many factors, such as natural selection,
mutations, genetic drift, and migrations. Molecular epidemiology evaluates the contribution …

PURPOSE Medullary thyroid carcinoma (MTC) is an aggressive neuroendocrine tumor
(NET) arising from the calcitonin-producing C cells. Unlike other NETs, there is no widely …

Medullary thyroid carcinoma (MTC) is a rare nonfollicular cell-derived tumor. A robust
grading system may help better stratify patients at risk for recurrence and death from …

Purpose Thyroid cancer incidence has increased over recent decades with considerable
geographic variations in incidence patterns. Here, we analyzed temporal trends in the …

Grade, based on proliferative activity and tumor necrosis, has recently been shown to be
prognostic in medullary thyroid carcinoma (MTC) in multivariate analysis. The aim of this …

Background The impact of number of node metastases versus metastatic lymph node ratio
versus AJCC node category on biochemical cure in medullary thyroid cancer (MTC) is not …

Medullary thyroid carcinoma (MTC), an uncommon C cell thyroid malignancy, accounts for a
disproportionate number of thyroid cancer deaths. To predict MTC clinical behavior, the …

Objective Multiple endocrine neoplasia type 2A (MEN 2A) is a rare syndrome caused by
RET germline mutations and has been associated with primary hyperparathyroidism (PHPT) …

Purpose MTC has varying clinical course. In cases with metastatic disease (meta-MTC)
further therapeutic modalities (locoregional and/or Tyrosine-Kinase-Inhibitors, TKIs) are …

Background Medullary thyroid carcinoma (MTC) is a rare cancer of parafollicular C‐cell
origin. The International MTC Grading System (IMTCGS) incorporates mitotic activity, the …