Heart failure (HF) is a complex clinical syndrome characterized by the activation of at least
several neurohumoral pathways that have a common role in maintaining cardiac output and …

Liver sinusoidal endothelial cells (LSEC) form a unique barrier between the liver sinusoids
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …

Endothelium is a community of endothelial cells (ECs), which line the blood and lymphatic
vessels, thus forming an interface between the tissues and the blood or lympha. This …

Renal tissue injury initiates inflammatory and fibrotic processes that occur to promote
regeneration and repair. After renal injury, damaged tissue releases cytokines and …

Myofibroblasts are non-muscle contractile cells that play a key physiologically role in organs
such as the stem villi of the human placenta during physiological pregnancy. They are able …

The vascular endothelium occupies a catalog of functions that contribute to the homeostasis
of the cardiovascular system. It is a physically active barrier between circulating blood and …

Cardiac remodelling is classified as physiological (in response to growth, exercise and
pregnancy) or pathological (in response to inflammation, ischaemia, ischaemia/reperfusion …

Abstract Slug (SNAI2), a member of the well-conserved Snail family of transcription factors,
has multiple developmental roles, including in epithelial-to-mesenchymal transition (EMT) …

Background & Aims Previous studies demonstrated that autophagy is protective in
hepatocytes and macrophages, but detrimental in hepatic stellate cells in chronic liver …

Heart failure with preserved ejection fraction (HFpEF) is an increasingly studied entity
accounting for 50% of all diagnosed heart failure and that has claimed its own dignity being …