Diabetes-associated long-term hyperglycaemia leads to oxidative stress-mediated fibrosis in
different tissues and organs. Endothelial-to-mesenchymal-transition (EndMT) appears to …

Cardiac fibrosis is implicit in all forms of heart disease but there are no effective treatments.
In this report, we investigate the role of the multi-functional enzyme Transglutaminase 2 …

Overexpression of interleukin 6 (IL-6) has been proposed to contribute to pulmonary fibrosis
and other fibrotic diseases. However, the regulatory mechanisms and the role of IL-6 in …

Transforming growth factor beta (TGF-β) is crucial for regulation of the endothelial cell (EC)
homeostasis. Perturbation of TGF-β signaling leads to pathological conditions in the …

Sustained angiogenesis and increased PD-L1 expression on endothelial and carcinoma
cells contribute toward fostering an immunosuppressive microenvironment suitable for tumor …

Abstract Systemic Sclerosis (SSc) pathogenesis involves multiple immunological, vascular
and fibroproliferative abnormalities that contribute to a severe and complex clinical picture …

Previous studies have reported that endothelial-to-mesenchymal transition (EndoMT)
contributes to pathological fibrosis in proliferative diabetic retinopathy (PDR). The …

Oncostain M, a member of the IL-6 family of cytokines, is produced by immune cells in
response to infections and tissue injury. OSM has a broad, often context-dependent effect on …

Every organ develops fibrosis that compromises functions in response to infections, injuries,
or diseases. The cornea is a relatively simple, avascular organ that offers an exceptional …

The disease criteria used by the World Health Organization (WHO) were applied to human
biological aging in order to assess whether aging can be classified as a disease. These …