Since most of the body's extracellular matrix (ECM) is composed of collagen and elastin, we
believe the choice of these materials is key for the future and promise of tissue engineering …

Idiopathic pulmonary fibrosis (IPF) is a progressive disease with an unknown cause. Two
drugs, nintedanib and pirfenidone, have been shown to slow, but not stop, disease …

Keloid disorder, a group of fibroproliferative skin disorders, is clinically comprised of keloids,
hypertrophic scars, keloidalis nuchae, and acne keloidalis. The prototype of these disorders …

Systemic sclerosis (SSc) is a connective tissue disease of autoimmune origin characterized
by vascular dysfunction and extensive fibrosis of the skin and visceral organs. Vascular …

Kidney fibrosis is a common process of various kidney diseases leading to end‐stage renal
failure irrespective of etiology. Myofibroblasts are crucial mediators in kidney fibrosis through …

Endothelial injury may play a central role in connecting three features that characterize SSc
pathogenesis: vasculopathy, chronic inflammation, and fibrosis. Our understanding of the …

Aims Hepatic capillaries are lined with specialized liver sinusoidal endothelial cells (LSECs)
which support macromolecule passage to hepatocytes and prevent fibrosis by keeping …

Aims Endothelial to mesenchymal transition (EndMT) is closely related to atherosclerosis.
Herein, we aim to determine whether miR-122 is involved in EndMT and the underlying …

Background We have previously reported arterial remodelling in patients with idiopathic
pulmonary fibrosis (IPF) and suggested that endothelial-to-mesenchymal transition (EndMT) …

Endothelial plasticity enables the cells to switch their phenotype according to the
surrounding vascular microenvironment. MicroRNAs (miRNAs) are small noncoding RNAs …