Immune checkpoint blockade in pancreatic cancer: trudging through the immune desert
Pancreatic cancer (PC) has exceptionally high mortality due to ineffective treatment
strategies. Immunotherapy, which mobilizes the immune system to fight against cancer, has …
strategies. Immunotherapy, which mobilizes the immune system to fight against cancer, has …
KRAS-related proteins in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease with a high
mortality rate. Genetic and biochemical studies have shown that RAS signaling mediated by …
mortality rate. Genetic and biochemical studies have shown that RAS signaling mediated by …
Kaempferol Inhibits Pancreatic Cancer Cell Growth and Migration through the Blockade of EGFR-Related Pathway In Vitro
J Lee, JH Kim - PloS one, 2016 - journals.plos.org
Pancreatic cancer is one of the most appalling cancers with a pessimistic prognosis. Despite
many therapies, there has been no improvement of survival rates. In this study, we assessed …
many therapies, there has been no improvement of survival rates. In this study, we assessed …
Roles of EGFR and KRAS and their downstream signaling pathways in pancreatic cancer and pancreatic cancer stem cells
TL Fitzgerald, K Lertpiriyapong, L Cocco… - Advances in biological …, 2015 - Elsevier
Pancreatic cancer is currently the fourth most common cancer, is increasing in incidence
and soon will be the second leading cause of cancer death in the USA. This is a deadly …
and soon will be the second leading cause of cancer death in the USA. This is a deadly …
Aptamer-conjugated PLGA nanoparticles for delivery and imaging of cancer therapeutic drugs
Most problems associated with chemotherapeutic agents involve non-specific cytotoxicity,
low intratumoral accumulation and drug resistance. Targeted drug delivery systems (TDDS) …
low intratumoral accumulation and drug resistance. Targeted drug delivery systems (TDDS) …
[HTML][HTML] CD73's potential as an immunotherapy target in gastrointestinal cancers
JB Harvey, LH Phan, OE Villarreal… - Frontiers in …, 2020 - frontiersin.org
CD73, a cell surface 5′ nucleotidase that generates adenosine, has emerged as an
attractive therapeutic target for reprogramming cancer cells and the tumor microenvironment …
attractive therapeutic target for reprogramming cancer cells and the tumor microenvironment …
Impacting Pancreatic Cancer Therapy in Heterotypic in Vitro Organoids and in Vivo Tumors with Specificity-Tuned, NIR-Activable Photoimmunonanoconjugates …
Despite untiring efforts to develop therapies for pancreatic ductal adenocarcinoma (PDAC),
survival statistics remain dismal, necessitating distinct approaches. Photodynamic priming …
survival statistics remain dismal, necessitating distinct approaches. Photodynamic priming …
Cancer and diabetes: the interlinking metabolic pathways and repurposing actions of antidiabetic drugs
Cancers are regarded as one of the main causes of death and result in high health burden
worldwide. The management of cancer include chemotherapy, surgery and radiotherapy …
worldwide. The management of cancer include chemotherapy, surgery and radiotherapy …
Developing effective combination therapy for pancreatic cancer: An overview
AL Miller, PL Garcia, KJ Yoon - Pharmacological research, 2020 - Elsevier
Pancreatic cancer is a fatal disease. The five-year survival for patients with all stages of this
tumor type is less than 10%, with a majority of patients dying from drug resistant, metastatic …
tumor type is less than 10%, with a majority of patients dying from drug resistant, metastatic …
Recent progress of benzimidazole hybrids for anticancer potential
This review presents the detailed account of factors leading to cancer and design strategy
for the synthesis of benzimidazole derivatives as anticancer agents. The recent survey for …
for the synthesis of benzimidazole derivatives as anticancer agents. The recent survey for …