Neurons that synthesize and release 5-hydroxytryptamine (5-HT; serotonin) express a core
set of genes that establish and maintain this neurotransmitter phenotype and distinguish …

Highlights•Terminal selector control terminal steps of neuronal identity acquisition.•Terminal
selectors establish and maintain neuron type-specific identity features.•Terminal selectors …

Organogenesis requires the complex interactions of multiple cell lineages that coordinate
their expansion, differentiation, and maturation over time. Here, we profile the cell types …

One reason that many central nervous system injuries, including those arising from traumatic
brain injury, spinal cord injury, and stroke, have limited recovery of function is that neurons …

Among the brainstem raphe nuclei, the dorsal raphe nucleus (DR) contains the greatest
number of Pet1-lineage neurons, a predominantly serotonergic group distributed throughout …

The continuing fascination with serotonin (5‐hydroxytryptamine, 5‐HT) as a nervous system
chemical messenger began with its discovery in the brains of mammals in 1953. Among the …

Changing serotonin (5-hydroxytryptamine, 5-HT) brain levels during critical periods in
development has long-lasting effects on brain function, particularly on later …

Serotonin (5-HT) is a crucial neuromodulator linked to many psychiatric disorders. However,
after more than 60 years of study, its role in behavior remains poorly understood, in part …

A common organizational feature of nervous systems is the existence of groups of neurons
that share common traits but can be divided into individual subtypes based on anatomical or …

Neurons are remarkably long-lived, non-dividing cells that must maintain their functional
features (eg, electrical properties, chemical signaling) for extended periods of time–decades …