Recent advances in mRNA cancer vaccines: meeting challenges and embracing opportunities

B Wang, J Pei, S Xu, J Liu, J Yu - Frontiers in immunology, 2023 - frontiersin.org
Since the successful application of messenger RNA (mRNA) vaccines in preventing COVID-
19, researchers have been striving to develop mRNA vaccines for clinical use, including …

[HTML][HTML] Recent advances in the development of sialyltransferase inhibitors to control cancer metastasis: A comprehensive review

R Al Saoud, A Hamrouni, A Idris, WK Mousa… - Biomedicine & …, 2023 - Elsevier
Metastasis accounts for the majority of cancer-associated mortalities, representing a huge
health and economic burden. One of the mechanisms that enables metastasis is …

A journey of challenges and victories: a bibliometric worldview of nanomedicine since the 21st century

J Wang, W Zhao, Z Zhang, X Liu, T Xie… - Advanced …, 2024 - Wiley Online Library
Nanotechnology profoundly affects the advancement of medicine. Limitations in diagnosing
and treating cancer and chronic diseases promote the growth of nanomedicine. However …

Biomaterials-mediated CRISPR/Cas9 delivery: recent challenges and opportunities in gene therapy

AK Dubey, E Mostafavi - Frontiers in Chemistry, 2023 - frontiersin.org
The use of biomaterials in delivering CRISPR/Cas9 for gene therapy in infectious diseases
holds tremendous potential. This innovative approach combines the advantages of …

An overview of the use of nanoparticles in vaccine development

D Lozano, V Larraga, M Vallet-Regí, M Manzano - Nanomaterials, 2023 - mdpi.com
Vaccines represent one of the most significant advancements in public health since they
prevented morbidity and mortality in millions of people every year. Conventionally, vaccine …

Metal–Drug Coordination Nanoparticles and Hydrogels for Enhanced Delivery

KY Wong, Z Nie, MS Wong, Y Wang… - Advanced Materials, 2024 - Wiley Online Library
Drug delivery is a key component of nanomedicine, and conventional delivery relies on the
adsorption or encapsulation of drug molecules to a nanomaterial. Many delivery vehicles …

Delivery of immunostimulatory cargos in nanocarriers enhances anti-tumoral nanovaccine efficacy

J Schunke, V Mailänder, K Landfester… - International Journal of …, 2023 - mdpi.com
Finding a long-term cure for tumor patients still represents a major challenge.
Immunotherapies offer promising therapy options, since they are designed to specifically …

Lipid Nanoparticle (LNP) Delivery Carrier-Assisted Targeted Controlled Release mRNA Vaccines in Tumor Immunity

L Wu, X Li, X Qian, S Wang, J Liu, J Yan - Vaccines, 2024 - mdpi.com
In recent years, lipid nanoparticles (LNPs) have attracted extensive attention in tumor
immunotherapy. Targeting immune cells in cancer therapy has become a strategy of great …

Advancing CAR-based immunotherapies in solid tumors: CAR-macrophages and neutrophils

Y Liang, Q Xu, Q Gao - Frontiers in Immunology, 2023 - frontiersin.org
Macrophages and neutrophils are the main components of the innate immune system and
play important roles in promoting angiogenesis, extracellular matrix remodeling, cancer cell …

Role of NLRP3 inflammasome in nanoparticle adjuvant-mediated immune response

M Ahmed, P Kurungottu, K Swetha, S Atla… - Biomaterials …, 2024 - pubs.rsc.org
The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin
domain-containing 3 (NLRP3) inflammasome is pivotal in orchestrating the immune …