Reactive oxygen species such as superoxide anion radicals (O2−) and hydrogen peroxide
(H2O2) have for long time been recognized as undesirable by‐products of the oxidative …

Dependency on tumor oxygenation is one of the major features of radiation therapy and this
has led many radiation biologists and oncologists to focus on tumor hypoxia. The first …

Tumor hypoxia has been attracting increasing attention in the fields of radiation biology and
oncology since Thomlinson and Gray detected hypoxic cells in malignant solid tumors and …

Objective Non-alcoholic fatty liver disease (NAFLD) is an aberrant lipid metabolism disease.
Hypoxia inducible factor-1 (HIF-1α) is a transcription factor which plays an important part in …

Abstract Hypoxia-inducible factor 1 (HIF-1) has been associated with distant tumor
metastasis; however, its function in multiple metastatic processes has not yet been fully …

The mechanistic target of rapamycin (mTOR) pathway is involved in the function and growth
of the placenta during pregnancy. The mTOR pathway responds to nutrient availability and …

Aggressive tumors typically demonstrate a high glycolytic rate, which results in resistance to
radiation therapy and cancer progression via several molecular and physiologic …

Cancer complexity constantly challenges the way that clinicians manage breast cancer
therapy. Tumor heterogeneity and intratumoral stroma characteristics allow cells with …

Resveratrol is gaining attention for its anticancer effects and is also recognized for its
antioxidant properties and influence on glucose metabolism. Augmented reactive oxygen …

Cancer cells gain a growth advantage through the so-called Warburg effect by shifting
glucose metabolism from oxidative phosphorylation to aerobic glycolysis. Hypoxia-inducible …