Hypoxia in solid tumors is an important predictor of poor clinical outcome to radiotherapy.
Both physicochemical and biological processes contribute to a reduced sensitivity of hypoxic …

Cadmium, a highly toxic environmental pollutant, is reported to induce toxicity and apoptosis
in multiple organs and cells, all possibly contributing to apoptosis in certain …

Hypoxia is a big roadblock for cancer radiotherapy, in which the hypoxia-inducible factor
(HIF-1) creates a microenvironment and cancer cells' intrinsic signaling networks conferring …

Tumor hypoxia is positively correlated with tumor aggressiveness and hence is a negative
prognostic factor in cancer. As normal cells usually do not experience such low oxygen …

The microenvironment plays a vital role in tumor progression, and hypoxia is a typical
microenvironment feature in nearly all solid tumors. In this study, we focused on elucidating …

Cell metabolism is characterised by the highly coordinated conversion of nutrients into
energy and biomass. In solid cancers, hypoxia, nutrient deficiencies, and tumour vasculature …

Colorectal cancer (CRC) is a common tumor type with a high mortality rate, in part due to
intrinsic drug resistance. Although bevacizumab, a VEGF-directed neutralizing antibody, is …

The disease-free survival following radiotherapy is often limited by the development of
second/secondary cancers. This significant impediment to effective cancer treatment …

Background: Head and neck squamous cell carcinoma (HNSCC) are resistant to standard
treatments, partly due to cancer stem cells (CSCs) localised in hypoxic niches. Compared to …

Hypoxia is associated with tumor radioresistance; therefore, a predictive marker for tumor
hypoxia and a rational target to overcome it have been sought to realize personalized …