Brain ischemia and reperfusion (I/R) injury occurs in various pathological conditions, but
there is no effective treatment currently available in clinical practice. Methylene blue (MB) is …

Hippocampus is one of the brain regions in which neuroplastic changes occur. Paradigms
such as environmental enrichment (ENR) have been used to prevent or delay the …

N-Linked glycosylation (N-glycosylation) of proteins has long been associated with
oncogenesis, but not until recently have the molecular mechanisms underlying this …

Abstract Hypoxia-inducible factor-1 (HIF-1) has been reported to promote tumour
radioresistance; therefore, it is recognised as an excellent target during radiation therapy …

Celastrol, a tripterine derived from the traditional Chinese medicine plant Tripterygium
wilfordii Hook F.(“Thunder of God Vine”), has been reported to have multiple effects, such as …

Abstract Hypoxia-inducible factor 1 (HIF1) is a master transcription factor that induces the
transcription of genes involved in the metabolism and behavior of stem cells. HIF1-mediated …

Hypoxic cells dynamically translocate during tumor growth and after radiotherapy. The most
desirable direction for therapy targeting hypoxic cells is combining imaging and therapy …

Worldwide, nasopharyngeal carcinoma (NPC) is a rare head and neck cancer; however, it is
a common malignancy in southern China. Radiotherapy is the most important treatment …

Lymphocyte antigen 6 complex, locus E (LY6E) has been implicated in the malignant
progression of various types of cancers; however, the underlying mechanism remains …

The significant burden of resistance to conventional anticancer treatments in patients with
advanced disease has prompted the need to explore alternative therapeutic strategies. The …