Naked mole-rats (NMR; Heterocephalus glaber) display extreme longevity and resistance to
cancer. Here, we examined whether autophagy contributes to the longevity of NMRs by …

Renal cell carcinoma (RCC) is a constellation of malignancies of different histological
subtypes arising from the renal parenchyma. The clear cell histological subtype (ccRCC) …

For many tumor types concurrent chemoradiation is the standard of care for locally
advanced disease. Despite this intense treatment overall survival is still poor in various solid …

Reduced radiosensitivity of lung cancer cells represents a pivotal obstacle in clinical
oncology. The hypoxia-inducible factor (HIF)-1α plays a crucial role in radiosensitivity, but …

Background Hypoxia regulates gene expression via the transcription factor HIF (Hypoxia-
Inducible Factor). Little is known regarding HIF expression and function in primary bone …

Gliomas, the most common primary brain tumors, have low survival rates and poorly defined
molecular mechanisms to target for treatment. Serine/arginine SR protein kinases 1 …

The development of blood vessels by the process of angiogenesis underpins the growth and
metastasis of many tumour types. Various angiogenesis inhibitors targeted against vascular …

Hypoxia is an important factor in tumor biology and is both a predictive and a prognostic
factor in non–small cell lung cancer. The negative effect of low oxygenation on radiation …

Macrophages (Mψ) are the major component of infiltrating leukocytes in tumors and exhibit
distinct phenotypes according to the microenvironment. We have recently found that signal …

Cancer metabolism is critical for understanding the mechanism of tumorigenesis, yet the
understanding is still challenging. We studied gene-metabolism regulatory interactions and …