Mucus is a selective barrier to particles and molecules, preventing penetration to the
epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery …

Aspergillus species are globally ubiquitous saprophytes found in a variety of ecological
niches. Almost 200 species of aspergilli have been identified, less than 20 of which are …

Respiratory fungal infection is a severe clinical problem, especially in patients with
compromised immune functions. Aspergillus, Cryptococcus, Pneumocystis, and endemic …

Aspergillus fumigatus is the most prevalent airborne fungal pathogen in developed
countries, and in immunocompromised patients causes a usually fatal invasive aspergillosis …

Inhalation of fungal spores (conidia) occurs commonly and, in specific circumstances, can
result in invasive disease. We investigated the murine inflammatory response to conidia of …

All humans are continuously exposed to inhaled Aspergillus conidia, yet healthy hosts clear
the organism without developing disease and without the development of antibody-or cell …

Tumor necrosis factor α (TNF-α) blockade has emerged as a useful therapy for collagen
vascular diseases or graft-vs-host disease. Fungal infections complicating such therapy …

Alveolar macrophages and neutrophils mediate innate immune defense against the
opportunistic fungal pathogen Aspergillus fumigatus and are believed to be essential for …

Since IL-37 transgenic mice possesses broad anti-inflammatory properties, we assessed
whether recombinant IL-37 affects inflammation in a murine model of invasive pulmonary …

Despite improvements in treatment and diagnostics over the last two decades, invasive
aspergillosis (IA) remains a devastating fungal disease. The number of …