Role of exosomes in the pathogenesis, diagnosis, and treatment of central nervous system diseases

Y Fan, Z Chen, M Zhang - Journal of Translational Medicine, 2022 - Springer
Central nervous system (CNS) diseases, such as multiple sclerosis, Alzheimer's disease
(AD), and Parkinson's disease (PD), affect millions of people around the world. Great efforts …

Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine

D Lopes, J Lopes, M Pereira-Silva, D Peixoto… - Military Medical …, 2023 - Springer
A bio-inspired strategy has recently been developed for camouflaging nanocarriers with
biomembranes, such as natural cell membranes or subcellular structure-derived …

Advances in mRNA non-viral delivery approaches

ML Ibba, G Ciccone, CL Esposito, S Catuogno… - Advanced drug delivery …, 2021 - Elsevier
Messenger RNAs (mRNAs) present a great potential as therapeutics for the treatment and
prevention of a wide range of human pathologies, allowing for protein replacement …

Critical review of nucleic acid nanotechnology to identify gaps and inform a strategy for accelerated clinical translation

KA Afonin, MA Dobrovolskaia, W Ke… - Advanced drug delivery …, 2022 - Elsevier
With numerous recent advances, the field of therapeutic nucleic acid nanotechnology is now
poised for clinical translation supported by several examples of FDA-approved nucleic acid …

[HTML][HTML] Lipid carriers for mRNA delivery

W Zhang, Y Jiang, Y He, H Boucetta, J Wu… - … Pharmaceutica Sinica B, 2023 - Elsevier
Messenger RNA (mRNA) is the template for protein biosynthesis and is emerging as an
essential active molecule to combat various diseases, including viral infection and cancer …

Research advances of engineered exosomes as drug delivery carrier

L Huang, E Wu, J Liao, Z Wei, J Wang, Z Chen - ACS omega, 2023 - ACS Publications
Exosomes are nanoscale vesicles secreted by living cells that have similar membrane
composition to parental cells and carry a variety of proteins, lipids, and nucleic acids …

Exosomal circular RNA: a signature for lung cancer progression

BM Hussen, SR Abdullah, GS Hama Faraj… - Cancer Cell …, 2022 - Springer
Membrane vesicles having a diameter of 30–150 nm are known as exosomes. Several
cancer types secrete exosomes, which may contain proteins, circular RNAs (circRNAs) …

Microenvironment of pancreatic inflammation: calling for nanotechnology for diagnosis and treatment

L Liu, Y Zhang, X Li, J Deng - Journal of Nanobiotechnology, 2023 - Springer
Acute pancreatitis (AP) is a common and life-threatening digestive disorder. However, its
diagnosis and treatment are still impeded by our limited understanding of its etiology …

An overview of the Stability and Delivery challenges of Commercial Nucleic Acid therapeutics

RG Ingle, WJ Fang - Pharmaceutics, 2023 - mdpi.com
Nucleic acid (NA)-based biopharmaceuticals have emerged as promising therapeutic
modalities. NA therapeutics are a diverse class of RNA and DNA and include antisense …

Expanding structural space for immunomodulatory nucleic acid nanoparticles via spatial arrangement of their therapeutic moieties

M Chandler, L Rolband, MB Johnson… - Advanced functional …, 2022 - Wiley Online Library
Different therapeutic nucleic acids (TNAs) can be unified in a single structure by their
elongation with short oligonucleotides designed to self‐assemble into nucleic acid …