Over the past few years, therapeutic drug monitoring (TDM) has gained practical
significance in antimicrobial precision therapy. Yet two categories of mainstream TDM …

Drug monitoring is one strategy of antibiotic stewardship to face antimicrobial resistance.
This strategy could have a determinant role in critically ill patients treated with carbapenems …

Background Optimizing antimicrobial therapy to attain drug exposure that limits the
emergence of resistance, effectively treats the infection, and reduces the risk of side effects …

Objectives Critically ill patients in intensive care unit (ICU) are susceptible to infectious
diseases, thus empirical therapy is recommended. However, the therapeutic effect in ICU …

An ultra‐high pressure liquid chromatography high‐resolution mass spectrometric (UHPLC–
HRMS) method was developed for the simultaneous and sensitive quantification of 10 β …

Background: Optimization of antimicrobial therapy is a challenge in critically ill patients who
develop extreme interindividual and intraindividual pharmacokinetic variability. Therapeutic …

Meropenem (MER) is widely used to treat complicated and serious infections. Therapeutic
drug monitoring (TDM) provides a valid clinical tool to avoid suboptimal concentrations and …

Since its inception, liquid chromatography-mass spectrometry (LC-MS) has been
continuously improved upon in many aspects, including instrument capabilities, sensitivity …

Cefazolin (CFZ) plus metronidazole (MTZ) is commonly used for perioperative antibiotic
prophylaxis. An HPLC-UV method is described for the simultaneous determination of total or …

Background: Guidelines recommend empirical therapy with piperacillin/tazobactam (TZP) for
spontaneous bacterial peritonitis (SBP) with low risk of multidrug-resistant organisms …