In this study, a new analytical method was developed and validated for the simultaneous
analysis of antibiotic drugs (amoxicillin, cefotaxime, ciprofloxacin, clindamycin, linezolid …

Background: Recent studies indicate that a high proportion of patients in the intensive care
unit fail to attain adequate antibiotic levels. Thus, there is a need to monitor the antibiotic …

Beta-lactam antibiotics are of vital importance for the treatment of infections in a broad range
of patients. Although most systemically administered antibiotics will be excreted renally, a …

Objective To develop and validate an UPLC–MS/MS assay for simultaneous determination
of the total concentration of ceftazidime, ciprofloxacin, flucloxacillin, piperacillin, tazobactam …

Abstract The World Health Organization recommends that infants be exclusively breastfed
for the first 6 months. Antibiotics are among the most commonly prescribed drugs for …

Background Pharmacokinetic studies of cefuroxime by ultra‐performance liquid
chromatography tandem mass spectrometry (UPLC‐MS/MS) have been limited to …

Meropenem is an ultrabroad-spectrum antimicrobial agent that is often recommended for the
treatment of bacterial meningitis (BM) in children. However, a subtherapeutic phenomenon …

Rationale The consistency evaluation of generic drugs is important for the overall
reformation of drug registration in China. In this study, we used meropenem as a model drug …

目的: 通过分析不同药物组合下的药物浓度达标率和治疗反应以及影响药物浓度变化,
探讨抗菌药物治疗药物监测(TDM) 优化临床给药方案, 对重症感染患者完全缓解率和疗效评价 …

Dihydroxy-4-methoxybenzyl alcohol (DHMBA) has been considered a prominent active
compound in shellfish, while its confirmatory analysis method in shellfish has not been well …