Various preclinical models have been developed to clarify the pathophysiology of prostate
cancer (PCa). Traditional PCa cell lines from clinical metastatic lesions, as exemplified by …

The human 6-transmembrane epithelial antigen of prostate (STEAP) family comprises
STEAP1, STEAP2, STEAP3, and STEAP4. All of these proteins are unique to mammals and …

The androgen receptor is a major driver of prostate cancer and inhibition of its transcriptional
activity using competitive antagonists, such as enzalutamide remains a frontline therapy for …

Neuroendocrine prostate cancer (NEPC) is an aggressive subtype of prostate cancer that
most commonly evolves from preexisting prostate adenocarcinoma (PCA). Using next …

BACKGROUND The majority of the prostatic cancers are adenocarcinomas characterized by
glandular formation and the expression of luminal differentiation markers androgen receptor …

CD44 is a multifunctional protein involved in cell adhesion and signaling. The role of CD44
in prostate cancer (PCa) development and progression is controversial with studies showing …

Prostate cancer (PCa) shows strong dependence on the androgen receptor (AR) pathway.
Here, we show that squalene epoxidase (SQLE), an enzyme of the cholesterol biosynthesis …

Transcriptional dysregulation induced by aberrant transcription factors (TF) is a key feature
of cancer, but its global influence on drug sensitivity has not been examined. Here, we infer …

Context: Cell lines derived from human cancers provide critical tools to study disease
mechanisms and develop novel therapies. Recent reports indicate that up to 36% of cell …

Prostate epithelial cells from both normal and cancer tissues, grown in three-dimensional
(3D) culture as spheroids, represent promising in vitro models for the study of normal and …