Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …

Our incomplete understanding of the link between Alzheimer's Disease pathology and
symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies …

Alzheimer's disease (AD), the most common form of dementia, is highly prevalent in older
adults. The main clinical feature is the progressive decline of memory function, which …

The symptoms of Alzheimer disease reflect a loss of neural circuit integrity in the brain, but
neurons do not work in isolation. Emerging evidence suggests that the intricate balance of …

Multiple sclerosis (MS) is a demyelinating, autoimmune disease of the central nervous
system. While work has focused on myelin and axon loss in MS, less is known about …

Microglia shape the synaptic environment in health and disease, but synapses do not exist
in a vacuum. Instead, pre-and postsynaptic terminals are surrounded by extracellular matrix …

The synapse has consistently been considered a vulnerable and critical target within
Alzheimer's disease, and synapse loss is, to date, one of the main biological correlates of …

Alzheimer's disease (AD) is a main cause of dementia, accounting for up to 75% of all
dementia cases. Pathophysiological processes described for AD progression involve …

Alzheimer's disease (AD) is a gradually growing irreversible illness of the brain that almost
affects every fifth person (aged> 80 years) in the world. World Health Organization (WHO) …

Neuroinflammation with excess microglial activation and synaptic dysfunction are early
symptoms of most neurological diseases. However, how microglia-associated …