Protein–RNA docking is still an open question. One of the main challenges is to develop an
effective scoring function that can discriminate near‐native structures from the incorrect …

Deciphering the structural and energetic determinants of protein-RNA interactions harbors
the potential to understand key cell processes at molecular level, such as gene expression …

Ribonucleases (RNases) are valuable tools applied in the analysis of RNA sequence,
structure and function. Their substrate specificity is limited to recognition of single bases or …

RNA-protein (RNP) interactions generally are required for RNA function. At least 5% of
human genes code for RNA-binding proteins. Whereas many approaches can identify the …

Cellular prion protein (PrP) misfolds into an aberrant and infectious scrapie form (PrP Sc)
that lead to fatal transmissible spongiform encephalopathies (TSEs). Association of prions …

Protein–RNA recognition is highly affinity-driven and regulates a wide array of cellular
functions. In this study, we have curated a binding affinity data set of 40 protein–RNA …

Computational prediction of RNA-protein complex 3D structures includes two basic steps:
one is sampling possible structures and another is scoring the sampled structures to pick out …

Biological processes are often mediated by complexes formed between proteins and
various biomolecules. The 3D structures of such protein–biomolecule complexes provide …

Many critical processes in the cell involve direct binding between RNAs and proteins,
making it imperative to fully understand the physicochemical principles behind such …

FOXP2 is a member of the P subfamily of FOX transcription factors, the DNA-binding domain
of which is the winged helix forkhead domain (FHD). In this work we show that the FOXP2 …